Pub. Date : 2013 Nov
PMID : 24001946
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The nephrotoxic potential of cisplatin has been ascribed to its accumulation in the, renal tubular cells generating reactive oxygen species (ROS), activation of Bax, increased secretion of, TNFalpha and activation of certain inflammatory mediators like cytokines. | Cisplatin | tumor necrosis factor | Rattus norvegicus |
| 2 | Pretreatment of rosiglitazone prevents cisplatin induced nephrotoxicity which was, clearly evident from the renal biochemical parameters like reduced BUN, creatinine and TNFalpha levels, and increased albumin levels, which was also supported by histopathological studies of the kidneys. | Cisplatin | tumor necrosis factor | Rattus norvegicus |