PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23942093-6	2013	To define the mechanisms of anticancer effects of metformin, we examined its influence on AMPK activation and NF-kappaB pathway.	Metformin	50-59	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	90-94	
23942093-8	2013	Activation of AMPK by metformin not only inhibited HCC cells growth in vitro and in vivo, but also augmented cisplatin-induced growth inhibition in HCC cells.	Metformin	22-31	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	14-18	
23942093-9	2013	Knockdown of AMPKalpha expression can greatly decrease the inhibitory effect of metformin, indicating that AMPK activation is required for the anticancer action of metformin.	Metformin	80-89	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	13-17	
23942093-9	2013	Knockdown of AMPKalpha expression can greatly decrease the inhibitory effect of metformin, indicating that AMPK activation is required for the anticancer action of metformin.	Metformin	164-173	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	13-17	
23942093-10	2013	Mechanistically, metformin/AMPK activation inhibited NF-kappaB signaling through upregulation of IkappaBalpha.	Metformin	17-26	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	27-31