Pub. Date : 2013
PMID : 23861910
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alpha-linolenic acid exerts an endothelial protective effect against high glucose injury via PI3K/Akt pathway. | alpha-Linolenic Acid | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 2 | Treatment with ALA (50 micromol/L) increased Akt phosphorylation, attenuated P-selectin and ICAM-1 expressions and thus inhibited neutrophils adhesion in HUVECs exposed to high glucose, all of which was blocked by the PI3K inhibitors LY294002 and wortmannin. | alpha-Linolenic Acid | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 3 | The anti-adhesive effect of ALA against high glucose injury may partially be mediated by the PI3K/Akt pathway. | alpha-Linolenic Acid | AKT serine/threonine kinase 1 | Rattus norvegicus |