Title : Angiotensin receptor blockers and statins could alleviate atrial fibrosis via regulating platelet-derived growth factor/Rac1/nuclear factor-kappa B Axis.

Pub. Date : 2013

PMID : 23794945






3 Functional Relationships(s)
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1 The highest reduction could be seen after treatment with irbesartan and simvastatin in combination (all P<0.001).There were strongly positive correlations between AngII or CVF with PDGF, Rac1, NF-kappaB, and among PDGF, Rac1 and NF-kappaB (all P<0.05). Irbesartan Rac family small GTPase 1 Homo sapiens
2 The highest reduction could be seen after treatment with irbesartan and simvastatin in combination (all P<0.001).There were strongly positive correlations between AngII or CVF with PDGF, Rac1, NF-kappaB, and among PDGF, Rac1 and NF-kappaB (all P<0.05). Irbesartan Rac family small GTPase 1 Homo sapiens
3 CONCLUSIONS: Irbesartan or/and simvastatin can improve atrial fibrosis by regulating PDGF/Rac1/NF-kappaB axis. Irbesartan Rac family small GTPase 1 Homo sapiens