PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23794945-6 2013 The highest reduction could be seen after treatment with irbesartan and simvastatin in combination (all P<0.001).There were strongly positive correlations between AngII or CVF with PDGF, Rac1, NF-kappaB, and among PDGF, Rac1 and NF-kappaB (all P<0.05). Irbesartan 57-67 Rac family small GTPase 1 Homo sapiens 190-194 23794945-6 2013 The highest reduction could be seen after treatment with irbesartan and simvastatin in combination (all P<0.001).There were strongly positive correlations between AngII or CVF with PDGF, Rac1, NF-kappaB, and among PDGF, Rac1 and NF-kappaB (all P<0.05). Irbesartan 57-67 Rac family small GTPase 1 Homo sapiens 223-227 23794945-7 2013 CONCLUSIONS: Irbesartan or/and simvastatin can improve atrial fibrosis by regulating PDGF/Rac1/NF-kappaB axis. Irbesartan 13-23 Rac family small GTPase 1 Homo sapiens 90-94