Pub. Date : 2013
PMID : 23762150
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Resveratrol inhibits alpha-melanocyte-stimulating hormone signaling, viability, and invasiveness in melanoma cells. | Resveratrol | pro-opiomelanocortin-alpha | Mus musculus |
| 2 | This study was aimed to examine the effect of resveratrol, an abundant ingredient of grape and medicinal plants, on alpha -MSH signaling, viability, and invasiveness in melanoma cells. | Resveratrol | pro-opiomelanocortin-alpha | Mus musculus |
| 3 | The upregulated expression of alpha -MSH signaling-related molecules beta -catenin, c-Kit, and MITF was suppressed by resveratrol and/or STI571 treatment. | Resveratrol | pro-opiomelanocortin-alpha | Mus musculus |
| 4 | Nuclear translocation of MITF, a hallmark of alpha -MSH signaling activation, was inhibited by combined treatment of resveratrol and STI571. | Resveratrol | pro-opiomelanocortin-alpha | Mus musculus |
| 5 | In conclusion, resveratrol enhances STI571 effect on suppressing the alpha -MSH signaling, viability, and invasiveness in melanoma cells. | Resveratrol | pro-opiomelanocortin-alpha | Mus musculus |