Title : Alzheimer's disease: identification and development of β-secretase (BACE-1) binding fragments and inhibitors by dynamic ligation screening (DLS).

Pub. Date : 2013 Jul

PMID : 23757181






1 Functional Relationships(s)
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1 Incubation of this CRI with the protease, a FRET substrate, and one amine per well taken from an amine library, which was assembled by a maximum common substructure (MCS) approach, revealed the fragment 3-(3-aminophenyl)-2H-chromen-2-one (1) to be a competitive BACE-1 inhibitor that enhanced the activity of the CRI. 3-(3-aminophenyl)-2h-chromen-2-one ( beta-secretase 1 Homo sapiens