Protein Name beta-secretase 1
Organism Homo sapiens
Gene ID 23621
Gene Symbol


UniProt P56817 (BACE1_HUMAN), A0A024R3E8 (A0A024R3E8_HUMAN), A0A024R3D5 (A0A024R3D5_HUMAN), B7Z3Z4 (B7Z3Z4_HUMAN), A0A024R3F9 (A0A024R3F9_HUMAN), B7Z3K2 (B7Z3K2_HUMAN), A0A024R3D7 (A0A024R3D7_HUMAN), Q5W9H2 (Q5W9H2_HUMAN)
Relationships Total Number of functionally related compound(s) : 881
Total Number of Articles : 821

beta-secretase 1

Gene Summary

This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]

  • beta-secretase 1
  • APP beta-secretase
  • asp 2
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