PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23757181-5 2013 Incubation of this CRI with the protease, a FRET substrate, and one amine per well taken from an amine library, which was assembled by a maximum common substructure (MCS) approach, revealed the fragment 3-(3-aminophenyl)-2H-chromen-2-one (1) to be a competitive BACE-1 inhibitor that enhanced the activity of the CRI. 3-(3-aminophenyl)-2h-chromen-2-one ( 203-239 beta-secretase 1 Homo sapiens 262-268