Pub. Date : 2013 Jun
PMID : 23730215
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have also found that a single mutation of the Tyr(644) or Tyr(664) residue of the C terminus of NPM-ALK to phenylalanine decreases significantly, but does not completely abolish, the association between NPM-ALK and IGF-IR. | Tyrosine | ALK receptor tyrosine kinase | Homo sapiens |
| 2 | We have also found that a single mutation of the Tyr(644) or Tyr(664) residue of the C terminus of NPM-ALK to phenylalanine decreases significantly, but does not completely abolish, the association between NPM-ALK and IGF-IR. | Tyrosine | ALK receptor tyrosine kinase | Homo sapiens |
| 3 | We have also found that a single mutation of the Tyr(644) or Tyr(664) residue of the C terminus of NPM-ALK to phenylalanine decreases significantly, but does not completely abolish, the association between NPM-ALK and IGF-IR. | Tyrosine | ALK receptor tyrosine kinase | Homo sapiens |
| 4 | We have also found that a single mutation of the Tyr(644) or Tyr(664) residue of the C terminus of NPM-ALK to phenylalanine decreases significantly, but does not completely abolish, the association between NPM-ALK and IGF-IR. | Tyrosine | ALK receptor tyrosine kinase | Homo sapiens |
| 5 | The purpose of this study was to determine whether the dual mutation of Tyr(644) and Tyr(664) abrogates the association and interactions between NPM-ALK and IGF-IR. | Tyrosine | ALK receptor tyrosine kinase | Homo sapiens |
| 6 | The purpose of this study was to determine whether the dual mutation of Tyr(644) and Tyr(664) abrogates the association and interactions between NPM-ALK and IGF-IR. | Tyrosine | ALK receptor tyrosine kinase | Homo sapiens |
| 7 | Importantly, we found that the dual mutation of Tyr(644) and Tyr(664) diminishes the oncogenic effects of NPM-ALK, including its ability to induce anchorage-independent colony formation and to sustain cellular transformation, proliferation, and migration. | Tyrosine | ALK receptor tyrosine kinase | Homo sapiens |
| 8 | Importantly, we found that the dual mutation of Tyr(644) and Tyr(664) diminishes the oncogenic effects of NPM-ALK, including its ability to induce anchorage-independent colony formation and to sustain cellular transformation, proliferation, and migration. | Tyrosine | ALK receptor tyrosine kinase | Homo sapiens |
| 9 | Furthermore, the association between NPM-ALK and IGF-IR through Tyr(644) and Tyr(664) appears to contribute to maintaining the stability of NPM-ALK protein. | Tyrosine | ALK receptor tyrosine kinase | Homo sapiens |
| 10 | Furthermore, the association between NPM-ALK and IGF-IR through Tyr(644) and Tyr(664) appears to contribute to maintaining the stability of NPM-ALK protein. | Tyrosine | ALK receptor tyrosine kinase | Homo sapiens |
| 11 | Furthermore, the association between NPM-ALK and IGF-IR through Tyr(644) and Tyr(664) appears to contribute to maintaining the stability of NPM-ALK protein. | Tyrosine | ALK receptor tyrosine kinase | Homo sapiens |