Title : Tetramethylpyrazine attenuates TNF-α-induced iNOS expression in human endothelial cells: Involvement of Syk-mediated activation of PI3K-IKK-IκB signaling pathways.

Pub. Date : 2013 Aug 15

PMID : 23726836






2 Functional Relationships(s)
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1 Spleen tyrosine kinase (Syk) inhibitor piceatannol significantly inhibited NO production. 3,3',4,5'-tetrahydroxystilbene spleen associated tyrosine kinase Homo sapiens
2 Furthermore, piceatannol obviously suppressed TNF-alpha-induced IkappaB phosphorylation and the downstream NF-kappaB activation, suggesting that Syk is an upstream key regulator in the activation of PI3K/IKK/IkappaB-mediated signaling. 3,3',4,5'-tetrahydroxystilbene spleen associated tyrosine kinase Homo sapiens