Title : Effects of a sitagliptin safety alert on prescription behaviour for oral antihyperglycaemic drugs: a propensity score-matched cohort study of prescription receipt data in Japan.

Pub. Date : 2013 Aug

PMID : 23700263






3 Functional Relationships(s)
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1 The primary outcome measure of this study was dose of glimepiride, glibenclamide or gliclazide prescribed for DPP-4 and non-DPP-4 patients. glimepiride dipeptidyl peptidase 4 Homo sapiens
2 The mean prescribed glimepiride dose in DPP-4 patients was also reduced from 2.79 +- 1.81 mg in Period 1 (before the alert) to 2.38 +- 1.71 mg in Period 2 (after the alert) [p < 0.0001], whereas the corresponding change in the case of non-DPP-4 patients was from 2.01 +- 1.56 mg to 2.01 +- 1.54 mg (p = 0.94). glimepiride dipeptidyl peptidase 4 Homo sapiens
3 The mean prescribed glimepiride dose in DPP-4 patients was also reduced from 2.79 +- 1.81 mg in Period 1 (before the alert) to 2.38 +- 1.71 mg in Period 2 (after the alert) [p < 0.0001], whereas the corresponding change in the case of non-DPP-4 patients was from 2.01 +- 1.56 mg to 2.01 +- 1.54 mg (p = 0.94). glimepiride dipeptidyl peptidase 4 Homo sapiens