Title : Recombinant human protein C derivatives: altered response to calcium resulting in enhanced activation by thrombin.

Pub. Date : 1990 Aug

PMID : 2369894






2 Functional Relationships(s)
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1 These same single amino acid substitutions enhanced the affinity of the thrombomodulin-thrombin complex for the substrate at 3 mM calcium 3-(Gly-substitution) to 6-(Phe-substitution) fold, either without influencing kcat (Gly-substitution) or with a 2.5-fold decrease of kcat. Glycine coagulation factor II, thrombin Homo sapiens
2 These same single amino acid substitutions enhanced the affinity of the thrombomodulin-thrombin complex for the substrate at 3 mM calcium 3-(Gly-substitution) to 6-(Phe-substitution) fold, either without influencing kcat (Gly-substitution) or with a 2.5-fold decrease of kcat. Glycine coagulation factor II, thrombin Homo sapiens