Pub. Date : 2013
PMID : 23573137
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The protective effect of alpha-lipoic Acid in lipopolysaccharide-induced acute lung injury is mediated by heme oxygenase-1. | Thioctic Acid | heme oxygenase 1 | Homo sapiens |
| 2 | The aim of study was to test the hypothesis that the protection of ALA against lipopolysaccharide-(LPS-) induced acute lung injury (ALI) is mediated by HO-1. | Thioctic Acid | heme oxygenase 1 | Homo sapiens |
| 3 | Interestingly, treatment with ALA significantly increased nuclear factor-erythroid 2-related factor 2 (Nrf2) activation and HO-1 expression in lungs of ALI. | Thioctic Acid | heme oxygenase 1 | Homo sapiens |
| 4 | However, blocking HO-1 activity by tin protoporphyrin IX (SnPP), an HO-1 inhibitor, markedly abolished these beneficial effects of ALA in LPS-induced ALI. | Thioctic Acid | heme oxygenase 1 | Homo sapiens |
| 5 | However, blocking HO-1 activity by tin protoporphyrin IX (SnPP), an HO-1 inhibitor, markedly abolished these beneficial effects of ALA in LPS-induced ALI. | Thioctic Acid | heme oxygenase 1 | Homo sapiens |
| 6 | These results suggest that the protection mechanism of ALA may be through HO-1 induction and in turn suppressing NF- kappa B-mediated inflammatory responses. | Thioctic Acid | heme oxygenase 1 | Homo sapiens |