Title : Pure curcumin increases the expression of SOCS1 and SOCS3 in myeloproliferative neoplasms through suppressing class I histone deacetylases.

Pub. Date : 2013 Jul

PMID : 23430957






3 Functional Relationships(s)
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1 Thus, HDAC8 plays an important role in the modulation of SOCS1 and SOCS3 by curcumin. Curcumin histone deacetylase 8 Homo sapiens
2 Finally, curcumin markedly inhibited HDAC activities and decreased HDAC8 levels in primary MPN cells. Curcumin histone deacetylase 8 Homo sapiens
3 Taken together, our data uncover a regulatory mechanism of SOCS1 and SOCS3 through inhibition of HDAC activity (especially HDAC8) by curcumin. Curcumin histone deacetylase 8 Homo sapiens