Protein Name histone deacetylase 8
Organism Homo sapiens
Gene ID 55869
Gene Symbol

HDAC8

UniProt Q9BY41 (HDAC8_HUMAN)
Relationships Total Number of functionally related compound(s) : 267
Total Number of Articles : 213
Description

histone deacetylase 8

Gene Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

synonyms
  • histone deacetylase 8
  • histone deacetylase-like 1
  • protein deacetylase HDAC8
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Properties