Pub. Date : 2013 Mar
PMID : 23415873
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Furthermore, curcumin increased the expression of the ER stress associated transcriptional factors XBP-1, cleaved p50ATF6alpha and C/EBP homologous protein (CHOP) in human CD4+ and Jurkat T cells. | Curcumin | DNA damage inducible transcript 3 | Homo sapiens |
2 | Furthermore, curcumin increased the expression of the ER stress associated transcriptional factors XBP-1, cleaved p50ATF6alpha and C/EBP homologous protein (CHOP) in human CD4+ and Jurkat T cells. | Curcumin | DNA damage inducible transcript 3 | Homo sapiens |
3 | In PHA-activated T cells, curcumin further enhanced PHA-induced CHOP expression and reduced the expression of the anti-apoptotic protein Bcl-2. | Curcumin | DNA damage inducible transcript 3 | Homo sapiens |
4 | Finally, curcumin treatment induced apoptotic cell death in activated T cells via eliciting an excessive ER stress response, which was reversed by the ER-stress inhibitor 4-phenylbutyric acid or transfection with CHOP-specific siRNA. | Curcumin | DNA damage inducible transcript 3 | Homo sapiens |