Title : Curcumin induces apoptotic cell death of activated human CD4+ T cells via increasing endoplasmic reticulum stress and mitochondrial dysfunction.

Pub. Date : 2013 Mar

PMID : 23415873






4 Functional Relationships(s)
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1 Furthermore, curcumin increased the expression of the ER stress associated transcriptional factors XBP-1, cleaved p50ATF6alpha and C/EBP homologous protein (CHOP) in human CD4+ and Jurkat T cells. Curcumin DNA damage inducible transcript 3 Homo sapiens
2 Furthermore, curcumin increased the expression of the ER stress associated transcriptional factors XBP-1, cleaved p50ATF6alpha and C/EBP homologous protein (CHOP) in human CD4+ and Jurkat T cells. Curcumin DNA damage inducible transcript 3 Homo sapiens
3 In PHA-activated T cells, curcumin further enhanced PHA-induced CHOP expression and reduced the expression of the anti-apoptotic protein Bcl-2. Curcumin DNA damage inducible transcript 3 Homo sapiens
4 Finally, curcumin treatment induced apoptotic cell death in activated T cells via eliciting an excessive ER stress response, which was reversed by the ER-stress inhibitor 4-phenylbutyric acid or transfection with CHOP-specific siRNA. Curcumin DNA damage inducible transcript 3 Homo sapiens