Title : The JNk/NFkappaB pathway is required to activate murine lymphocytes induced by a sulfated polysaccharide from Ecklonia cava.

Pub. Date : 2013 Mar

PMID : 23262141






3 Functional Relationships(s)
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1 Therefore, we investigated whether the sulfated polysaccharide (SP) of E. cava specifically activates the protein kinases (MAPKs) and nuclear factor-kappaB (NFkappaB) to incite immune responses. sp nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
2 Moreover, co-application of both JNK and NFkappaB inhibitors completely blocked the proliferation of lymphocytes even in the presence of SP. sp nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus
3 CONCLUSION: These results suggest that SP induced T and B cell responses via both JNK and NFkappaB pathways. sp nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus