Pub. Date : 2013 Feb 15
PMID : 23238299
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study demonstrates that chelidonine and an alkaloid extract from Chelidonium majus, which contains protoberberine and benzo[c]phenanthridine alkaloids, has the ability to overcome MDR of different cancer cell lines through interaction with ABC-transporters, CYP3A4 and GST, by induction of apoptosis, and cytotoxic effects. | Alkaloids | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In addition, chelidonine and the alkaloid extract inhibited the activity of the drug modifying enzymes CYP3A4 and GST in a dose-dependent manner. | Alkaloids | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | Treatment of Caco-2 cells with 50 mug/ml alkaloid extract and 50 muM chelidonine for up to 48 h resulted in a significant decrease in mRNA levels of P-gp/MDR1, MRP1, BCRP, CYP3A4, GST, and hPXR and in a significant increase in caspase-3 and caspase-8 mRNA. | Alkaloids | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |