Title : Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats.

Pub. Date : 2013 Feb 4

PMID : 23219579






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats. Dexmedetomidine mitogen activated protein kinase 3 Rattus norvegicus
2 The increasing expressions of p-Akt and p-ERK1/2 induced by Dex in the ischemic hemisphere were markedly inhibited by LY294002 (or wortmannin) and U0126 (or PD98059), respectively. Dexmedetomidine mitogen activated protein kinase 3 Rattus norvegicus
3 Our data demonstrated that treatment with Dex reduced cerebral injury in rats exposed to transient focal I/R, and this was mediated by the activation of the PI3K/Akt and ERK1/2 pathways as well the phosphorylation of downstream GSK-3beta. Dexmedetomidine mitogen activated protein kinase 3 Rattus norvegicus