PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23219579-0 2013 Both PI3K/Akt and ERK1/2 pathways participate in the protection by dexmedetomidine against transient focal cerebral ischemia/reperfusion injury in rats. Dexmedetomidine 67-82 mitogen activated protein kinase 3 Rattus norvegicus 18-24 23219579-10 2013 The increasing expressions of p-Akt and p-ERK1/2 induced by Dex in the ischemic hemisphere were markedly inhibited by LY294002 (or wortmannin) and U0126 (or PD98059), respectively. Dexmedetomidine 60-63 mitogen activated protein kinase 3 Rattus norvegicus 42-48 23219579-12 2013 Our data demonstrated that treatment with Dex reduced cerebral injury in rats exposed to transient focal I/R, and this was mediated by the activation of the PI3K/Akt and ERK1/2 pathways as well the phosphorylation of downstream GSK-3beta. Dexmedetomidine 42-45 mitogen activated protein kinase 3 Rattus norvegicus 170-176