Title : The influence of inhibiting or stimulating the expression of the α3 subunit of the nicotinic receptor in SH-SY5Y cells on levels of amyloid-β peptide and β-secretase.

Pub. Date : 2013 Jan

PMID : 23201341






1 Functional Relationships(s)
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1 In contrast, when untransfected SH-SY5Y cells were exposed to nicotine, the levels of both alpha3 nAChR mRNA and protein were enhanced; while the levels of BACE1 mRNA and protein were diminished and the corresponding levels of BACE2 enhanced; and the level of Abeta in the culture medium was attenuated. Nicotine beta-secretase 2 Homo sapiens