| Protein Name | beta-secretase 2 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 25825 |
| Gene Symbol | BACE2 |
| UniProt | Q9Y5Z0 (BACE2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
130
Total Number of Articles : 130 |
Description |
beta-secretase 2 |
| Gene Summary |
This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| synonyms |
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| Properties | |