Pub. Date : 2012 Oct
PMID : 23170130
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Active P-glycoprotein (P-gp) molecules have been shown to transport steroids out of peripheral lymphocytes, resulting in poor responses to systemic steroid therapy in patients with systemic lupus erythematosus (SLE). | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Active P-glycoprotein (P-gp) molecules have been shown to transport steroids out of peripheral lymphocytes, resulting in poor responses to systemic steroid therapy in patients with systemic lupus erythematosus (SLE). | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Active P-glycoprotein (P-gp) molecules have been shown to transport steroids out of peripheral lymphocytes, resulting in poor responses to systemic steroid therapy in patients with systemic lupus erythematosus (SLE). | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Active P-glycoprotein (P-gp) molecules have been shown to transport steroids out of peripheral lymphocytes, resulting in poor responses to systemic steroid therapy in patients with systemic lupus erythematosus (SLE). | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | This study was carried out to investigate the correlation between the expression or activity of P-gp in peripheral lymphocytes and disease control in SLE patients with a long history of systemic steroid treatment. | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | In conclusion, the high expression levels of P-gp in the peripheral lymphocytes of SLE patients leads to poor disease control by systemic steroids. | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | Emodin, an active ingredient derived from Chinese herbs, possesses a promising effect for overcoming P-gp-mediated steroid resistance by inhibiting the P-gp efflux function. | Steroids | ATP binding cassette subfamily B member 1 | Homo sapiens |