Pub. Date : 2012 Oct
PMID : 23044308
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Pretreatment of WJ-MSCs with H2O2 increased the secretion of interleukin-6 (IL-6) into the cell culture supernatant by approximately 25-fold. | Hydrogen Peroxide | interleukin 6 | Mus musculus |
| 2 | Pretreatment of WJ-MSCs with H2O2 increased the secretion of interleukin-6 (IL-6) into the cell culture supernatant by approximately 25-fold. | Hydrogen Peroxide | interleukin 6 | Mus musculus |
| 3 | The culture supernatant from WJ-MSCs-H2O2 significantly increased the migration and proliferation of endothelial cells; these effects could be blocked using an anti-IL-6 antibody. | Hydrogen Peroxide | interleukin 6 | Mus musculus |
| 4 | CONCLUSIONS: This study demonstrates that H2O2 preconditioning significantly enhanced the therapeutic potential of WJ-MSCs, possibly by stimulating the production of IL-6 by WJ-MSCs, which may cause migration and proliferation of endothelial cells and increase neovascularization. | Hydrogen Peroxide | interleukin 6 | Mus musculus |