Title : Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1-2 signaling in synergy with EGFR.

Pub. Date : 2013 Jan 1

PMID : 23010081






3 Functional Relationships(s)
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1 Celecoxib induces proliferation and Amphiregulin production in colon subepithelial myofibroblasts, activating erk1-2 signaling in synergy with EGFR. Celecoxib mitogen-activated protein kinase 3 Homo sapiens
2 Celecoxib induces erk1-2 and Akt phosphorylation within 5". Celecoxib mitogen-activated protein kinase 3 Homo sapiens
3 According to these results the association with EGFR (or erk1-2) inhibitors could abolish the off-target activity of Celecoxib, possibly extending the potential of this drug for colon cancer prevention. Celecoxib mitogen-activated protein kinase 3 Homo sapiens