Title : Involvement of serotonin-mediated neurotransmission in the dorsal periaqueductal gray matter on cannabidiol chronic effects in panic-like responses in rats.

Pub. Date : 2013 Mar

PMID : 23007604






5 Functional Relationships(s)
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1 We also investigated if CBD effects on the ETM depend on facilitation of 5-HT1A-mediated neurotransmission in the DPAG. dpag 5-hydroxytryptamine receptor 1A Rattus norvegicus
2 To this latter aim, we verified if these effects would be prevented by intra-DPAG injection of the 5-HT1A receptor antagonist WAY100635 (0.37 nmol/0.2 muL). dpag 5-hydroxytryptamine receptor 1A Rattus norvegicus
3 Also, we verified, by in vivo microdialysis, if CBD chronic treatment increases serotonin (5-HT) release and, by quantitative polymerase chain reaction, if there are changes in 5HT-1A or 5HT-2C mRNA expression in DPAG. dpag 5-hydroxytryptamine receptor 1A Rattus norvegicus
4 CBD effects were prevented by DPAG injection of the 5-HT1A receptor antagonist. dpag 5-hydroxytryptamine receptor 1A Rattus norvegicus
5 CONCLUSIONS: Together, these findings suggest that repeated treatment with CBD induces anti-panic effects by acting on 5-HT1A receptors in DPAG. dpag 5-hydroxytryptamine receptor 1A Rattus norvegicus