Title : JAK-STAT pathway modulates the roles of iNOS and COX-2 in the cytoprotection of early phase of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress.

Pub. Date : 2012 Nov 7

PMID : 22995181






2 Functional Relationships(s)
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1 It was shown that (1) Preconditioning with H(2)O(2) at 100 mumol/L for 90 min in PC12 cells induced significant expression of iNOS and COX-2. Water nitric oxide synthase 2 Rattus norvegicus
2 (2) Pretreatment with the iNOS inhibitor AG (10 mumol/L) or the COX-2 inhibitor NS-398 (10 mumol/L) respectively 20min before H(2)O(2) preconditioning not only inhibits the increased expression of iNOS or COX-2 but also abrogates the protective effects of H(2)O(2) preconditioning against apoptosis induced by oxidative stress. Water nitric oxide synthase 2 Rattus norvegicus