Title : An in vitro screening to identify drug-resistant mutations for target-directed chemotherapeutic agents.

Pub. Date : 2012

PMID : 22956142






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using Imatinib and BCR/ABL as a paradigm for a drug-target pair, we reported a retroviral vector-based screening strategy to identify the spectrum of resistance-conferring mutations, which has helped in designing the next-generation BCR/ABL inhibitors such as Nilotinib, Dasatinib, and Ponatinib. ponatinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens
2 Using Imatinib and BCR/ABL as a paradigm for a drug-target pair, we reported a retroviral vector-based screening strategy to identify the spectrum of resistance-conferring mutations, which has helped in designing the next-generation BCR/ABL inhibitors such as Nilotinib, Dasatinib, and Ponatinib. ponatinib ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens