CPRiL

ABL1

ABL proto-oncogene 1, non-receptor tyrosine kinase

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]

• tyrosine-protein kinase ABL1
• ABL protooncogene 1 nonreceptor tyrosine kinase
• Abelson tyrosine-protein kinase 1
BCR-ABL1 p190
BCR/ABL e8a2 fusion
BCR/ABL1 e1a2 fusion protein
bcr/c-abl oncogene protein
c-abl oncogene 1, receptor tyrosine kinase
proto-oncogene c-Abl
proto-oncogene tyrosine-protein kinase ABL1
v-abl Abelson murine leukemia viral oncogene homolog 1
ABL
BCR-ABL
CHDSKM
JTK7
bcr/abl
c-ABL
c-ABL1
p150
v-abl