Protein Name ABL proto-oncogene 1, non-receptor tyrosine kinase
Organism Homo sapiens
Gene ID 25
Gene Symbol


UniProt P00519 (ABL1_HUMAN), A0A024R8E2 (A0A024R8E2_HUMAN), Q59FK4 (Q59FK4_HUMAN)
Relationships Total Number of functionally related compound(s) : 989
Total Number of Articles : 3577

ABL proto-oncogene 1, non-receptor tyrosine kinase

Gene Summary

This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]

  • tyrosine-protein kinase ABL1
  • ABL protooncogene 1 nonreceptor tyrosine kinase
  • Abelson tyrosine-protein kinase 1
Click to show/hide the synonyms