Title : β-Adrenergic receptor stimulation increases surface NKCC2 expression in rat thick ascending limbs in a process inhibited by phosphodiesterase 4.

Pub. Date : 2012 Nov 1

PMID : 22933300






1 Functional Relationships(s)
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1 The beta-adrenergic receptor antagonist propranolol or the PKA inhibitor H-89 completely blocked isoproterenol + IBMX-induced increase on surface NKCC2, while propranolol or H-89 alone had no effect. Isoproterenol protein kinase cAMP-activated catalytic subunit alpha Rattus norvegicus