Pub. Date : 2010 Feb 17
PMID : 22778820
14 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Involvement of protein kinase C in morphine tolerance at spinal levels of rats. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 2 | The present study was performed to investigate the possible role of protein kinase C (PKC) in morphine tolerance at spinal levels of rats. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 3 | The present study was performed to investigate the possible role of protein kinase C (PKC) in morphine tolerance at spinal levels of rats. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 4 | Interestingly, we found that there were significant increases in the content of PKC in the dorsal horn of the spinal cord and the dorsal root ganglion, but not in the ventral horn of the spinal cord, in rats with morphine tolerance determined by Western blot, suggesting that PKC is involved in morphine tolerance at spinal levels of rats. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 5 | Interestingly, we found that there were significant increases in the content of PKC in the dorsal horn of the spinal cord and the dorsal root ganglion, but not in the ventral horn of the spinal cord, in rats with morphine tolerance determined by Western blot, suggesting that PKC is involved in morphine tolerance at spinal levels of rats. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 6 | Interestingly, we found that there were significant increases in the content of PKC in the dorsal horn of the spinal cord and the dorsal root ganglion, but not in the ventral horn of the spinal cord, in rats with morphine tolerance determined by Western blot, suggesting that PKC is involved in morphine tolerance at spinal levels of rats. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 7 | Interestingly, we found that there were significant increases in the content of PKC in the dorsal horn of the spinal cord and the dorsal root ganglion, but not in the ventral horn of the spinal cord, in rats with morphine tolerance determined by Western blot, suggesting that PKC is involved in morphine tolerance at spinal levels of rats. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 8 | Furthermore, our results demonstrated that chronic intrathecal injection of the PKC inhibitor significantly inhibited the development of morphine tolerance. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 9 | Moreover, we found that the maintenance of morphine tolerance was blocked by intrathecal administration of a PKC inhibitor in rats, and the inhibitory effects of the PKC inhibitor on morphine tolerance lasted for more than two days. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 10 | Moreover, we found that the maintenance of morphine tolerance was blocked by intrathecal administration of a PKC inhibitor in rats, and the inhibitory effects of the PKC inhibitor on morphine tolerance lasted for more than two days. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 11 | Moreover, we found that the maintenance of morphine tolerance was blocked by intrathecal administration of a PKC inhibitor in rats, and the inhibitory effects of the PKC inhibitor on morphine tolerance lasted for more than two days. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 12 | Taken together, the present study clearly showed that PKC is involved in morphine tolerance at the spinal level of rats and that intrathecal administration of a PKC inhibitor can block the development and maintenance of morphine tolerance. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 13 | Taken together, the present study clearly showed that PKC is involved in morphine tolerance at the spinal level of rats and that intrathecal administration of a PKC inhibitor can block the development and maintenance of morphine tolerance. | Morphine | protein kinase C, gamma | Rattus norvegicus |
| 14 | Taken together, the present study clearly showed that PKC is involved in morphine tolerance at the spinal level of rats and that intrathecal administration of a PKC inhibitor can block the development and maintenance of morphine tolerance. | Morphine | protein kinase C, gamma | Rattus norvegicus |