PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22778820-0	2010	Involvement of protein kinase C in morphine tolerance at spinal levels of rats.	Morphine	35-43	protein kinase C, gamma	Rattus norvegicus	15-31	
22778820-1	2010	The present study was performed to investigate the possible role of protein kinase C (PKC) in morphine tolerance at spinal levels of rats.	Morphine	94-102	protein kinase C, gamma	Rattus norvegicus	68-84	
22778820-1	2010	The present study was performed to investigate the possible role of protein kinase C (PKC) in morphine tolerance at spinal levels of rats.	Morphine	94-102	protein kinase C, gamma	Rattus norvegicus	86-89	
22778820-4	2010	Interestingly, we found that there were significant increases in the content of PKC in the dorsal horn of the spinal cord and the dorsal root ganglion, but not in the ventral horn of the spinal cord, in rats with morphine tolerance determined by Western blot, suggesting that PKC is involved in morphine tolerance at spinal levels of rats.	Morphine	213-221	protein kinase C, gamma	Rattus norvegicus	80-83	
22778820-4	2010	Interestingly, we found that there were significant increases in the content of PKC in the dorsal horn of the spinal cord and the dorsal root ganglion, but not in the ventral horn of the spinal cord, in rats with morphine tolerance determined by Western blot, suggesting that PKC is involved in morphine tolerance at spinal levels of rats.	Morphine	213-221	protein kinase C, gamma	Rattus norvegicus	276-279	
22778820-4	2010	Interestingly, we found that there were significant increases in the content of PKC in the dorsal horn of the spinal cord and the dorsal root ganglion, but not in the ventral horn of the spinal cord, in rats with morphine tolerance determined by Western blot, suggesting that PKC is involved in morphine tolerance at spinal levels of rats.	Morphine	295-303	protein kinase C, gamma	Rattus norvegicus	80-83	
22778820-4	2010	Interestingly, we found that there were significant increases in the content of PKC in the dorsal horn of the spinal cord and the dorsal root ganglion, but not in the ventral horn of the spinal cord, in rats with morphine tolerance determined by Western blot, suggesting that PKC is involved in morphine tolerance at spinal levels of rats.	Morphine	295-303	protein kinase C, gamma	Rattus norvegicus	276-279	
22778820-5	2010	Furthermore, our results demonstrated that chronic intrathecal injection of the PKC inhibitor significantly inhibited the development of morphine tolerance.	Morphine	137-145	protein kinase C, gamma	Rattus norvegicus	80-83	
22778820-6	2010	Moreover, we found that the maintenance of morphine tolerance was blocked by intrathecal administration of a PKC inhibitor in rats, and the inhibitory effects of the PKC inhibitor on morphine tolerance lasted for more than two days.	Morphine	43-51	protein kinase C, gamma	Rattus norvegicus	109-112	
22778820-6	2010	Moreover, we found that the maintenance of morphine tolerance was blocked by intrathecal administration of a PKC inhibitor in rats, and the inhibitory effects of the PKC inhibitor on morphine tolerance lasted for more than two days.	Morphine	183-191	protein kinase C, gamma	Rattus norvegicus	109-112	
22778820-6	2010	Moreover, we found that the maintenance of morphine tolerance was blocked by intrathecal administration of a PKC inhibitor in rats, and the inhibitory effects of the PKC inhibitor on morphine tolerance lasted for more than two days.	Morphine	183-191	protein kinase C, gamma	Rattus norvegicus	166-169	
22778820-7	2010	Taken together, the present study clearly showed that PKC is involved in morphine tolerance at the spinal level of rats and that intrathecal administration of a PKC inhibitor can block the development and maintenance of morphine tolerance.	Morphine	73-81	protein kinase C, gamma	Rattus norvegicus	54-57	
22778820-7	2010	Taken together, the present study clearly showed that PKC is involved in morphine tolerance at the spinal level of rats and that intrathecal administration of a PKC inhibitor can block the development and maintenance of morphine tolerance.	Morphine	73-81	protein kinase C, gamma	Rattus norvegicus	161-164	
22778820-7	2010	Taken together, the present study clearly showed that PKC is involved in morphine tolerance at the spinal level of rats and that intrathecal administration of a PKC inhibitor can block the development and maintenance of morphine tolerance.	Morphine	220-228	protein kinase C, gamma	Rattus norvegicus	161-164