Pub. Date : 2012 Sep 29
PMID : 22728397
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibitory effect of JBP485 on renal excretion of acyclovir by the inhibition of OAT1 and OAT3. | Acyclovir | solute carrier family 22 member 6 | Homo sapiens |
| 2 | The purpose is to investigate whether the targets of drug-drug interactions (DDIs) between JBP485 and acyclovir are OAT1 and OAT3 in kidney. | Acyclovir | solute carrier family 22 member 6 | Homo sapiens |
| 3 | JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells. | Acyclovir | solute carrier family 22 member 6 | Homo sapiens |
| 4 | JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells. | Acyclovir | solute carrier family 22 member 6 | Homo sapiens |
| 5 | JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells. | Acyclovir | solute carrier family 22 member 6 | Homo sapiens |
| 6 | These results suggest that JBP485 inhibits the renal excretion of acyclovir by inhibiting renal transporters OAT1 and OAT3 in vivo and in vitro. | Acyclovir | solute carrier family 22 member 6 | Homo sapiens |