PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22728397-0 2012 Inhibitory effect of JBP485 on renal excretion of acyclovir by the inhibition of OAT1 and OAT3. Acyclovir 50-59 solute carrier family 22 member 6 Homo sapiens 81-85 22728397-1 2012 The purpose is to investigate whether the targets of drug-drug interactions (DDIs) between JBP485 and acyclovir are OAT1 and OAT3 in kidney. Acyclovir 102-111 solute carrier family 22 member 6 Homo sapiens 116-120 22728397-4 2012 JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells. Acyclovir 165-174 solute carrier family 22 member 6 Homo sapiens 24-28 22728397-4 2012 JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells. Acyclovir 165-174 solute carrier family 22 member 6 Homo sapiens 80-84 22728397-4 2012 JBP485 (a substrate for OAT1 and OAT3), p-aminohippurate (PAH) (a substrate for OAT1) and benzylpenicillin (PCG) (a substrate for OAT3) could decrease the uptake of acyclovir in kidney slices and in hOAT1-/hOAT3-HEK293 cells. Acyclovir 165-174 solute carrier family 22 member 6 Homo sapiens 199-204 22728397-5 2012 These results suggest that JBP485 inhibits the renal excretion of acyclovir by inhibiting renal transporters OAT1 and OAT3 in vivo and in vitro. Acyclovir 66-75 solute carrier family 22 member 6 Homo sapiens 109-113