Title : Atorvastatin preserves the integrity of endothelial adherens junctions by inhibiting vascular endothelial cadherin tyrosine phosphorylation.

Pub. Date : 2012 Aug 15

PMID : 22659162






3 Functional Relationships(s)
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1 Atorvastatin inhibited IL-1beta-induced Tyr phosphorylation of VE-cad by inhibiting RhoA and by dephosphorylating MLC. Tyrosine ras homolog family member A Homo sapiens
2 The attenuating effect of atorvastatin on VE-cad Tyr phosphorylation was reversed when RhoA was activated or MLC phosphatase was inhibited. Tyrosine ras homolog family member A Homo sapiens
3 Our study introduces a novel pleiotropic effect of atorvastatin and suggests that statins protect the integrity of AJs in ECs by inhibiting RhoA-mediated Tyr phosphorylation of VE-cad. Tyrosine ras homolog family member A Homo sapiens