Title : Opposing actions of ethanol and nicotine on microRNAs are mediated by nicotinic acetylcholine receptors in fetal cerebral cortical-derived neural progenitor cells.

Pub. Date : 2012 Oct

PMID : 22458409






4 Functional Relationships(s)
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1 Here, we tested in fetal NSCs the extent to which EtOH and nicotine coregulated known EtOH-sensitive (miR-9, miR-21, miR-153, and miR-335), a nicotine-sensitive miRNA (miR-140-3p), and mRNAs for nicotinic acetylcholine receptor (nAChR) subunits. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 Here, we tested in fetal NSCs the extent to which EtOH and nicotine coregulated known EtOH-sensitive (miR-9, miR-21, miR-153, and miR-335), a nicotine-sensitive miRNA (miR-140-3p), and mRNAs for nicotinic acetylcholine receptor (nAChR) subunits. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 Finally, EtOH decreased the expression of nAChR subunit mRNAs and, like mecamylamine, prevented the nicotine-associated increase in alpha4 and beta2 nAChR transcripts. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
4 CONCLUSIONS: EtOH and nicotine exert mutually antagonistic, nAChR-mediated effects on teratogen-sensitive miRNAs in fetal NSCs. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus