Pub. Date : 2012 Feb
PMID : 22430753
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Abiraterone acetate was developed to specifically inhibit cytochrome P450 (CYP)17A1, which is an essential enzyme in the biosynthesis of testosterone. | Abiraterone Acetate | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |
| 2 | However, adverse events resulting from elevated mineralocorticoid levels because of CYP17A1 inhibition, fluid retention and oedema, hypokalaemia, hypertension occurred in significantly more in abiraterone acetate plus prednisone than in placebo plus prednisone. | Abiraterone Acetate | cytochrome P450 family 17 subfamily A member 1 | Homo sapiens |