PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22430753-3 2012 Abiraterone acetate was developed to specifically inhibit cytochrome P450 (CYP)17A1, which is an essential enzyme in the biosynthesis of testosterone. Abiraterone Acetate 0-19 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 58-83 22430753-5 2012 However, adverse events resulting from elevated mineralocorticoid levels because of CYP17A1 inhibition, fluid retention and oedema, hypokalaemia, hypertension occurred in significantly more in abiraterone acetate plus prednisone than in placebo plus prednisone. Abiraterone Acetate 193-212 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 84-91