Pub. Date : 2012
PMID : 22393418
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Blocking autophagy prevents bortezomib-induced NF-kappaB activation by reducing I-kappaBalpha degradation in lymphoma cells. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |
| 2 | Since bortezomib treatment promoted I-kappaBalpha phosphorylation, ubiquitination and degradation, this suggests that the route of I-kappaBalpha degradation was not via the ubiquitin-proteasome degradation system. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |
| 3 | Since bortezomib treatment promoted I-kappaBalpha phosphorylation, ubiquitination and degradation, this suggests that the route of I-kappaBalpha degradation was not via the ubiquitin-proteasome degradation system. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |
| 4 | The autophagy inhibitor chloroquine (CQ) significantly inhibited bortezomib-induced I-kappaBalpha degradation, increased complex formation with NF-kappaB and reduced NF-kappaB nuclear translocation and DNA binding activity. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |
| 5 | In summary, bortezomib-induced autophagy confers relative DLBCL cell drug resistance by eliminating I-kappaBalpha. | Bortezomib | NFKB inhibitor alpha | Homo sapiens |