Title : Guanine-nucleotide exchange factor H1 mediates lipopolysaccharide-induced interleukin 6 and tumor necrosis factor α expression in endothelial cells via activation of nuclear factor κB.

Pub. Date : 2012 May

PMID : 22301607






1 Functional Relationships(s)
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1 Inhibition of GEF-H1 by specific small interfering RNA or inactivation of Rho-associated kinase with Y-27632 not only significantly reduced LPS-induced p38 and extracellular signal-regulated kinase 1/2 (ERK1/2) activities but also blocked LPS-induced NF-kappaB translocation and activation, thereby inhibiting IL-6/TNF-alpha mRNA and protein productions. Y 27632 mitogen-activated protein kinase 3 Homo sapiens