Pub. Date : 2012
PMID : 22291917
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice. | Superoxides | nitric oxide synthase 3, endothelial cell | Mus musculus |
| 2 | Here, we evaluate how endothelial nitric oxide synthase (eNOS) modulates leukocyte/endothelial- (L/E) and platelet/endothelial- (P/E) interactions in atherosclerosis and the production of nitric oxide (NO) and superoxide by the enzyme. | Superoxides | nitric oxide synthase 3, endothelial cell | Mus musculus |
| 3 | Here, we evaluate how endothelial nitric oxide synthase (eNOS) modulates leukocyte/endothelial- (L/E) and platelet/endothelial- (P/E) interactions in atherosclerosis and the production of nitric oxide (NO) and superoxide by the enzyme. | Superoxides | nitric oxide synthase 3, endothelial cell | Mus musculus |
| 4 | Pharmacological inhibition and genetic deletion of eNOS reduced vascular superoxide production, indicating uncoupling of the enzyme in apoE(-/-) vessels. | Superoxides | nitric oxide synthase 3, endothelial cell | Mus musculus |
| 5 | CONCLUSION: Overt plaque formation, increased vascular inflammation and L/E- interactions are associated with significant reduction of superoxide production in apoE(-/-)/eNOS(-/-) vessels. | Superoxides | nitric oxide synthase 3, endothelial cell | Mus musculus |