Protein Name nitric oxide synthase 3, endothelial cell
Organism Mus musculus
Gene ID 18127
Gene Symbol


UniProt P70313 (NOS3_MOUSE), Q8C5P3 (Q8C5P3_MOUSE)
Relationships Total Number of functionally related compound(s) : 555
Total Number of Articles : 1001

nitric oxide synthase 3, endothelial cell

Gene Summary

Enables nitric-oxide synthase activity and scaffold protein binding activity. Involved in several processes, including heart development; negative regulation of muscle hyperplasia; and smooth muscle hyperplasia. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; nitric oxide biosynthetic process; and regulation of metal ion transport. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; hemolymphoid system gland; and nervous system. Used to study aortic valve disease; essential hypertension; and persistent fetal circulation syndrome. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); artery disease (multiple); eye disease (multiple); reproductive organ cancer (multiple); and vasculitis (multiple). Orthologous to human NOS3 (nitric oxide synthase 3). [provided by Alliance of Genome Resources, Apr 2022]

  • nitric oxide synthase 3
  • EC-NOS
  • NOS type III
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