Title : Anti-cancer activities of tea epigallocatechin-3-gallate in breast cancer patients under radiotherapy.

Pub. Date : 2012 Feb

PMID : 22280355






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1 Addition of sera obtained from patients treated with combination of radiotherapy and EGCG feeding for 2-8 weeks to in vitro cultures of highly-metastatic human MDA-MB-231 breast cancer cells resulted in the following significant changes: (1) suppression of cell proliferation and invasion; (2) arrest of cell cycles at the G0/G1 phase; (3) reduction of activation of MMP9/MMP2, expressions of Bcl-2/Bax, c-Met receptor, NF-kappaB, and the phosphorylation of Akt. epigallocatechin gallate BCL2 apoptosis regulator Homo sapiens