Title : The non-steroidal anti-inflammatory drug indomethacin activates the eIF2α kinase PKR, causing a translational block in human colorectal cancer cells.

Pub. Date : 2012 Apr 15

PMID : 22268531






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The fact that indomethacin induced PKR activity in vitro, an effect reversed by the PKR inhibitor 2-aminopurine, suggests a direct effect of the drug in kinase activation. 2-Aminopurine eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens
2 The fact that indomethacin induced PKR activity in vitro, an effect reversed by the PKR inhibitor 2-aminopurine, suggests a direct effect of the drug in kinase activation. 2-Aminopurine eukaryotic translation initiation factor 2 alpha kinase 2 Homo sapiens