Protein Name eukaryotic translation initiation factor 2 alpha kinase 2
Organism Homo sapiens
Gene ID 5610
Gene Symbol


UniProt P19525 (E2AK2_HUMAN), Q8IW76 (Q8IW76_HUMAN)
Relationships Total Number of functionally related compound(s) : 296
Total Number of Articles : 391

eukaryotic translation initiation factor 2 alpha kinase 2

Gene Summary

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021]

  • interferon-induced, double-stranded RNA-activated protein kinase
  • P1/eIF-2A protein kinase
  • double stranded RNA activated protein kinase
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