Pub. Date : 2012 Mar 29
PMID : 22266344
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Regional c-Fos and FosB/DeltaFosB expression associated with chronic methamphetamine self-administration and methamphetamine-seeking behavior in rats. | Methamphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 2 | Regional c-Fos and FosB/DeltaFosB expression associated with chronic methamphetamine self-administration and methamphetamine-seeking behavior in rats. | Methamphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 3 | The results showed that acute METH produced a characteristic signature of Fos expression with elevations in striatal, cortical, and extended amygdala regions. | Methamphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 4 | Importantly, rats with a 3-week history of METH self-administration displayed similar regional Fos expression to rats receiving METH for the first time. | Methamphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 5 | Rats seeking, but not receiving, METH on the test day had augmented Fos in the lateral hypothalamus, septum, and vertical limb of the diagonal band of Broca, suggesting a primary role for these regions in METH-seeking behavior. | Methamphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |
| 6 | Overall, these results show persistent upregulated regional brain Fos and FosB/DeltaFosB expression with chronic METH self-administration and indicate a role for the lateral hypothalamus and lateral septum in METH-seeking behavior. | Methamphetamine | Fos proto-oncogene, AP-1 transcription factor subunit | Rattus norvegicus |