Title : Efficient synthesis and cell-based silencing activity of siRNAS that contain triazole backbone linkages.

Pub. Date : 2012 Feb 15

PMID : 22260772






2 Functional Relationships(s)
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1 Through the use of 4,4"-dimethoxytrityl (DMT) phosphoramidite chemistry, triazole backbone dimers were site-specifically incorporated throughout various siRNAs targeting both firefly luciferase and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene transcripts as representatives of an exogenous and endogenous gene, respectively. dmt glyceraldehyde-3-phosphate dehydrogenase Homo sapiens
2 Through the use of 4,4"-dimethoxytrityl (DMT) phosphoramidite chemistry, triazole backbone dimers were site-specifically incorporated throughout various siRNAs targeting both firefly luciferase and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene transcripts as representatives of an exogenous and endogenous gene, respectively. dmt glyceraldehyde-3-phosphate dehydrogenase Homo sapiens