Protein Name glyceraldehyde-3-phosphate dehydrogenase
Organism Homo sapiens
Gene ID 2597
Gene Symbol


UniProt P04406 (G3P_HUMAN), V9HVZ4 (V9HVZ4_HUMAN)
Relationships Total Number of functionally related compound(s) : 807
Total Number of Articles : 1063

glyceraldehyde-3-phosphate dehydrogenase

Gene Summary

This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

  • glyceraldehyde-3-phosphate dehydrogenase
  • OCAS, p38 component
  • Oct1 coactivator in S phase, 38 Kd component
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