Title : Involvement of SIRT1 in hypoxic down-regulation of c-Myc and β-catenin and hypoxic preconditioning effect of polyphenols.

Pub. Date : 2012 Mar 1

PMID : 22245592






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1 We also found that myricetin, quercetin, piceatannol and resveratrol up-regulated HIF-1alpha and down-regulated c-Myc, PHD2 and beta-catenin expressions via SIRT1 activation, in a manner that mimics hypoxic preconditioning. 3,3',4,5'-tetrahydroxystilbene hypoxia inducible factor 1 subunit alpha Homo sapiens